What is duplication in biology

Definition

Duplication is a genetic mutation where a portion of the DNA sequence is copied, resulting in multiple copies of that region within the chromosome.

This process can lead to changes in gene dosage, potentially causing overexpression of certain genes, which can significantly influence the development of inherited disorders.

5 Must Know Facts For Your Next Test

1. Duplications can arise through errors during DNA replication or recombination events, leading to structural variations in chromosomes.
2. Gene duplications are often considered a source of raw material for evolution, as they can allow for the development of new functions over time.
3. In humans, certain duplications have been linked to disorders like Charcot-Marie-Tooth disease and some types of cancer due to increased gene dosage effects.
4. Duplication events can vary in size, affecting small segments or larger regions encompassing multiple genes, which may complicate the genetic basis o