Miss south africa 1997
First black miss south africa...
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Professor of Cell and Developmental Biology
Ingram Professor of Cancer Research
Professor of Biochemistry
Co-Leader, Genome Maintenance Research Program/VICC
AAAS Fellow - 2012
Research Description
We study transcriptional regulation in normal and cancer cells.
Research in the laboratory falls into two broad categories: (1) Understanding how the oncoprotein transcription factor MYC works and how it can be targeted for therapeutic effect in cancer cells, and (2) Understanding how components of the ubiquitin–proteasome system control gene expression.
The term “MYC” refers to a family of three related oncogenes that are broadly over-expressed in cancer and contribute to an estimated 100,000 cancer deaths annually in the United States alone.
MYC proteins function as transcriptional regulators, controlling the expression of thousands of genes linked to cell growth, proliferation, metabolism, and genomic instability. MYC proteins are highly-validated but challenging drug targets